The activities of the orthopaedic research laboratories in the Department of Clinical Investigation focus on the development of novel therapeutic strategies that are based on biological principles. The envisaged approaches aim at improving and extending the pool of therapeutic tools at the orthopaedic surgeon`s disposal, with a view to improving the life-quality particularly of elderly patients, which is greatly impacted by the functionality of the musculoskeletal system. Thematically, the research topics cover degenerative, traumatic and neoplastic affections of the musculoskeletal system. Our group is especially interested in translational research, particularly in tissue-engineering projects. The goal of this research is to induce the repair of musculoskeletal tissues that do not undergo spontaneous healing, viz., which fail to heal in the absence of extrinsic, growth-factor-based stimulation (e.g., bone, cartilage, tendons and ligaments). Our group is also engaged on research in the basic-medical line, with a view to improving the current understanding of, and gaining novel insights into, the pathophysiology of orthopaedic diseases, and of laying a solid foundation for the conception of new therapeutic approaches. In our laboratories, the methodologies that are implemented to evaluate the data that are gleaned from both in-vitro and in-vivo experiments include histology, stereology, molecular biology, immunology, microcirculatory techniques and intravital microscopy. Clinical research is also undertaken, with a view to improving and further developing current therapies in the interests of our patients.
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