Our clinical research is dedicated to the development of new therapeutic strategies to diagnose and treat critical ischemia, which is the most frequent cause of failures and morbidity after flap surgery used for soft tissue reconstructions. Furthermore, we focus on the development of new 3D models intended to improve the aesthetic tissue reconstruction, especially in the face. In detail, the following therapeutic topics are addressed:
- Improving tissue oxygenation with artificial oxygen carriers
- Providing a suture-free anastomosis technique using an innovative and selective laser concept.
- Improving the collateral vascular network with the use of endothelial progenitor cells
These hypotheses are tested in various flap models in small rodents allowing for the assessment of hemodynamic variables and morphological changes with intravital microscopy. Partial oxygen tension (Clark probes) and oxidative energy metabolites (Microdialysis) can be continuously monitored in the tissue. These methods are under continuous clinical enhancement. In addition, various cytokines and growth factors interacting in angiogenesis are assessed. For this purpose, gene transfer and other molecular techniques are used. Both, the hypotheses and the methodologies are not specific to plastic surgery, and, thus, offer various interactions and collaborations with other research groups dealing with critical ischemia.
Please visit the external Group Website for more information.